Electrophoretic analyses of sera after treating dogs with beta-chloroethyl vesicants.

In a recent paper, Gilman and Philips (1) pointed out that the P-chloroethyl vesicants are extremely toxic compounds which have specific effects on the bone marrow, lymphoid tissues, and the intestinal mucosa. In addition, the systemic injury produced by these mustards causes a series of complex biochemical and physiological changes in the body. This investigation was undertaken to determine the effects of his@-chloroethyl) sulfide and three nitrogen mustards on the electrophoretic changes in the serum of dogs.